Genome-wide inference of regulatory networks in Streptomyces coelicolor.

ABSTRACT:

Background

The onset of antibiotics production in Streptomyces species is co-ordinated with differentiation events. An understanding of the genetic circuits that regulate these coupled biological phenomena is essential to discover and engineer the pharmacologically important natural products made by these species. The availability of genomic tools and access to a large warehouse of transcriptome data for the model organism, Streptomyces coelicolor, provides incentive to decipher the intricacies of the regulatory cascades and develop biologically meaningful hypotheses.

Results

In this study, more than 500 samples of genome-wide temporal transcriptome data, comprising wild-type and more than 25 regulatory gene mutants of Streptomyces coelicolor probed across multiple stress an

SUBMITTER: Castro-Melchor M 

PROVIDER: S-EPMC3224704 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature