Prediction and analysis of the modular structure of cytochrome P450 monooxygenases.

ABSTRACT:

Background

Cytochrome P450 monooxygenases (CYPs) form a vast and diverse family of highly variable sequences. They catalyze a wide variety of oxidative reactions and are therefore of great relevance in drug development and biotechnological applications. Despite their differences in sequence and substrate specificity, the structures of CYPs are highly similar. Although being in research focus for years, factors mediating selectivity and activity remain vague.

Description

This systematic comparison of CYPs based on the Cytochrome P450 Engineering Database (CYPED) involved sequence and structure analysis of more than 8000 sequences. 31 structures have been applied to generate a reliable structure-based HMM profile in order to predict structurally conserved regions. Therefore, i

SUBMITTER: Sirim D 

PROVIDER: S-EPMC3224734 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature