Prospective study on the mismatch concept in acute stroke patients within the first 24 h after symptom onset - 1000Plus study.

ABSTRACT:

Background

The mismatch between diffusion weighted imaging (DWI) lesion and perfusion imaging (PI) deficit volumes has been used as a surrogate of ischemic penumbra. This pathophysiology-orientated patient selection criterion for acute stroke treatment may have the potential to replace a fixed time window. Two recent trials - DEFUSE and EPITHET - investigated the mismatch concept in a multicenter prospective approach. Both studies randomized highly selected patients (n = 74/n = 100) and therefore confirmation in a large consecutive cohort is desirable. We here present a single-center approach with a 3T MR tomograph next door to the stroke unit, serving as a bridge from the ER to the stroke unit to screen all TIA and stroke patients. Our primary hypothesis is that the prognostic val

SUBMITTER: Hotter B 

PROVIDER: S-EPMC3224745 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature