Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone.

ABSTRACT:

Background

The effect on linear growth of daily long-term inhaled corticosteroid therapy in preschool-aged children with recurrent wheezing is controversial.

Objective

We sought to determine the effect of daily inhaled corticosteroid given for 2 years on linear growth in preschool children with recurrent wheezing.

Methods

Children aged 2 and 3 years with recurrent wheezing and positive modified Asthma Predictive Index scores were randomized to a 2-year treatment period of chlorofluorocarbon-delivered fluticasone propionate (176 μg/d) or masked placebo delivered through a valved chamber with a mask and then followed for 2 years off study medication. Height growth determined by means of stadiometry was compared between treatment groups.

Results

In the study cohor

SUBMITTER: Guilbert TW 

PROVIDER: S-EPMC3224818 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature