Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community.

ABSTRACT:

Background

Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial.

Methods and results

In 3120 Framingham cohort participants (mean age 58.4+/-9.7 years, 54% women), we related 10 biomarkers that represented inflammation (C-reactive protein and fibrinogen), neurohormonal activation (B-type natriuretic peptide [BNP] and N-terminal proatrial natriuretic peptide), oxidative stress (homocysteine), the renin-angiotensin-aldosterone system (renin and aldosterone), thrombosis and endothelial function (D-dimer and plasminogen activator inhibitor type 1), and microvascular damage (urinary albumin excretion; n=2673) to incident AF (n=209, 40% women) over a median follow-up of 9.7 yea

SUBMITTER: Schnabel RB 

PROVIDER: S-EPMC3224826 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature