Association of lysyl oxidase-like 1 gene polymorphisms with exfoliation syndrome in Koreans.

ABSTRACT:

Purpose

To evaluate the association of the lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) in the Korean population with exfoliation syndrome (XFS) and to investigate the association between the SNPs and phenotypes of XFS.

Methods

Eighty-nine unrelated patients with XFS and 146 unrelated control subjects were recruited. LOXL1 SNPs, rs1048661, rs3825942, and rs2165241, were genotyped by direct DNA sequencing. Association between cases and controls was analyzed and phenotypic features of XFS were compared in terms of the SNPs.

Results

The three SNPs were found to be significantly associated with XFS. After adjusting for rs3825942, rs2165241, and other factors influencing the prevalence of XFS, only rs1048661 among three SNPs remained significant (95%

SUBMITTER: Sagong M 

PROVIDER: S-EPMC3224829 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature