Clinical relevance of multidrug resistance gene expression in ovarian serous carcinoma effusions.

ABSTRACT: The presence of tumor cells in effusions within serosal cavities is a clinical manifestation of advanced-stage cancer and is generally associated with poor survival. Identifying molecular targets may help to design efficient treatments to eradicate these aggressive cancer cells and improve patient survival. Using a state-of-the-art TaqMan-based qRT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of 32 unpaired ovarian serous carcinoma effusion samples obtained at diagnosis or at disease recurrence following chemotherapy. MDR genes were selected a priori based on an extensive curation of the literature published during the last three decades. We found three gene signatures with a statistically significant correlation with overall survival (OS), response to treatment

SUBMITTER: Gillet JP 

PROVIDER: S-EPMC3224865 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature