Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse.

ABSTRACT:

Background

Nocturnin was originally identified by differential display as a circadian clock regulated gene with high expression at night in photoreceptors of the African clawed frog, Xenopus laevis. Although encoding a novel protein, the nocturnin cDNA had strong sequence similarity with a C-terminal domain of the yeast transcription factor CCR4, and with mouse and human ESTs. Since its original identification others have cloned mouse and human homologues of nocturnin/CCR4, and we have cloned a full-length cDNA from mouse retina, along with partial cDNAs from human, cow and chicken. The goal of this study was to determine the temporal pattern of nocturnin mRNA expression in multiple tissues of the mouse.

Results

cDNA sequence analysis revealed a high degree of conservation a

SUBMITTER: Wang Y 

PROVIDER: S-EPMC32249 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature