Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.

ABSTRACT:

Objective

USF1 is a ubiquitous transcription factor governing the expression of numerous genes of lipid and glucose metabolism. APOA5 is a well-established candidate gene regulating triglyceride (TG) levels and has been identified as a downstream target of upstream stimulatory factor. No detailed studies about the effect of APOA5 on atherosclerotic lesion formation have been conducted, nor has its potential interaction with USF1 been examined.

Methods and results

We analyzed allelic variants of USF1 and APOA5 in families (n=516) ascertained for atherogenic dyslipidemia and in an autopsy series of middle-aged men (n=300) with precise quantitative measurements of atherosclerotic lesions. The impact of previously associated APOA5 variants on TGs was observed in the dyslipidemic

SUBMITTER: Laurila PP 

PROVIDER: S-EPMC3224996 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature