Mechanisms of statin-induced myalgia assessed by physiogenomic associations.

ABSTRACT:

Objective

We investigated genetic variants predictive of muscular side effects in patients treated with statins. We utilized a physiogenomic approach to prototype a multi-gene panel correlated with statin-induced myalgia.

Background

Statin-induced myalgia occurs in ∼10% of lipid clinic outpatients. Its clinical manifestation may depend in part upon gene variation from patient to patient.

Methods

We genotyped 793 patients (377 with myalgia and 416 without) undergoing statin therapy at four U.S. outpatient clinic sites to evaluate 31 candidate genes from the literature for their association with statin-induced common myalgia.

Results

Three previously hypothesized candidate genes were validated: COQ2 (rs4693570) encoding para-hydroxybenzoate-polyprenyltransferase,

SUBMITTER: Ruano G 

PROVIDER: S-EPMC3224998 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature