Context-dependent transcriptional regulations between signal transduction pathways.

ABSTRACT:

Background

Cells coordinate their metabolism, proliferation, and cellular communication according to environmental cues through signal transduction. Because signal transduction has a primary role in cellular processes, many experimental techniques and approaches have emerged to discover the molecular components and dynamics that are dependent on cellular contexts. However, omics approaches based on genome-wide expression analysis data comparing one differing condition (e.g. complex disease patients and normal subjects) did not investigate the dynamics and inter-pathway cross-communication that are dependent on cellular contexts. Therefore, we introduce a new computational omics approach for discovering signal transduction pathways regulated by transcription and transcriptional regu

SUBMITTER: Hwang S 

PROVIDER: S-EPMC3225034 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature