Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States.

ABSTRACT:

Background

Elevated insulin resistance (IR), triglycerides (TG), body mass index (BMI), and waist circumference (WC) are features of the metabolic syndrome. Although several single-nucleotide polymorphisms (SNPs) associated with these traits have been reported, no study has reported their risk allele frequencies and effect sizes among the major U.S. race/ethnic groups in a nationally representative sample.

Methods

We compared the risk allele frequencies of eight SNPs previously associated with IR, TG, BMI, or WC by race/ethnicity (non-Hispanic white, non-Hispanic black, Mexican American) in 3,030 participants of the National Health and Nutrition Examination Study III (NHANES III). In regression models predicting IR, TG, BMI, WC, and metabolic syndrome, we tested whether the

SUBMITTER: Vassy JL 

PROVIDER: S-EPMC3225057 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature