Dataset Information

FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.

ABSTRACT:

Aim

To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus (HCV) cohort.

Methods

Patients with chronic HCV were randomized to receive interferon-based therapy for 24 (genotypes 2/3) or 48 (genotype 1) wk. FibroSURE™ (FS) was assessed at baseline and at week-12 post-treatment follow-up. Baseline biopsy for METAVIR was assessed by a single pathologist. FibroScan(®) transient elastography (TE) was performed during treatment in a patient subset.

Results

Two thousand and sixty patients (n = 253 in Asia) were classified as METAVIR F0-1 (n = 1682) or F2-4 (n = 378). For F2-4, FS (n = 2055) had sensitivity and specificity of 0.87 and 0.61, respectively, with area under the receiver-operating curve of 0.82; corresponding values for TE (n = 214) and combined FS/TE (n = 209) were 0.77, 0.88 and 0.88, and 0.93, 0.68 and 0.88. Overall FS/TE agreement for F2-4 was 71% (κ = 0.41) and higher in Asians vs non-Asians (κ = 0.86 vs 0.35; P < 0.001). Combined FS/TE had 97% accuracy in Asians (n = 33). Baseline FS (0.38 vs 0.51, P < 0.001) and TE (8.0 kPa vs 11.9 kPa, P = 0.006) scores were lower in patients with sustained virological response than in nonresponders, and were maintained through follow-up.

Conclusion

FS and TE may reliably differentiate mild from moderate-advanced disease, with a potential for high diagnostic accuracy in Asians with chronic HCV.

SUBMITTER: Patel K

PROVIDER: S-EPMC3225094 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Publications

FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.

Patel Keyur K Friedrich-Rust Mireen M Lurie Yoav Y Grigorescu Mircea M Stanciu Carol C Lee Chuan-Mo CM Schiff Eugene R ER Häussinger Dieter D Manns Michael P MP Gerken Guido G Colle Isabelle I Torbenson Michael M Pulkstenis Erik E Subramanian G Mani GM McHutchison John G JG Zeuzem Stefan S

World journal of gastroenterology 20111101 41

<h4>Aim</h4>To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus (HCV) cohort.<h4>Methods</h4>Patients with chronic HCV were randomized to receive interferon-based therapy for 24 (genotypes 2/3) or 48 (genotype 1) wk. FibroSURE™ (FS) was assessed at baseline and at week-12 post-treatment follow-up. Baseline biopsy for METAVIR was assessed by a single pathologist. FibroScan(®) transient elastography (TE) was performed ...[more]

PMID: 22147963

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Dataset Information

FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.

Aim

Methods

Results

Conclusion

Publications

FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.

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