MotifClick: prediction of cis-regulatory binding sites via merging cliques.

ABSTRACT:

Background

Although dozens of algorithms and tools have been developed to find a set of cis-regulatory binding sites called a motif in a set of intergenic sequences using various approaches, most of these tools focus on identifying binding sites that are significantly different from their background sequences. However, some motifs may have a similar nucleotide distribution to that of their background sequences. Therefore, such binding sites can be missed by these tools.

Results

Here, we present a graph-based polynomial-time algorithm, MotifClick, for the prediction of cis-regulatory binding sites, in particular, those that have a similar nucleotide distribution to that of their background sequences. To find binding sites with length k, we construct a graph using some 2(k-1)-

SUBMITTER: Zhang S 

PROVIDER: S-EPMC3225181 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature