Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract.

ABSTRACT:

Rationale

The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cells make important contributions to OFT formation and aortic arch remodeling. Although numerous signaling pathways, including Notch, have been implicated in this process, the role of epigenetics in OFT development remains largely unexplored.

Objective

Because histone deacetylases (Hdacs) play important roles in the epigenetic regulation of mammalian development, we have investigated the function of Hdac3, a class I Hdac, during cardiac neural crest development in mouse.

Methods and results

Using 2 neural crest drivers, Wnt1-Cre and Pax3(Cre), we show tha

SUBMITTER: Singh N 

PROVIDER: S-EPMC3225257 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature