A common variant in the β2-adrenergic receptor and risk of sudden cardiac death.

ABSTRACT:

Background

Homozygosity for a common nonsynonymous single nucleotide polymorphism (Gln27Glu) in the β(2)-adrenergic receptor gene (ADRB2) has been inconsistently associated with sudden cardiac death (SCD) in individual studies of small sample size.

Objective

The purpose of this study was to examine the association between the Gln27Glu polymorphism and SCD in a large combined sample of SCD cases.

Methods

Nested case-control analysis was performed for individuals of Caucasian ancestry enrolled in six prospective cohort studies. Genotypes for the Gln27Glu variant were determined for 492 cases of SCD and 1,388 controls matched for age, sex, cohort, follow-up time, and history of cardiovascular disease (CVD) and at the time of the blood draw. Individual studies were combin

SUBMITTER: Gavin MC 

PROVIDER: S-EPMC3225286 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature