Central nervous system gene expression changes in a transgenic mouse model for bovine spongiform encephalopathy.

ABSTRACT: Gene expression analysis has proven to be a very useful tool to gain knowledge of the factors involved in the pathogenesis of diseases, particularly in the initial or preclinical stages. With the aim of finding new data on the events occurring in the Central Nervous System in animals affected with Bovine Spongiform Encephalopathy, a comprehensive genome wide gene expression study was conducted at different time points of the disease on mice genetically modified to model the bovine species brain in terms of cellular prion protein. An accurate analysis of the information generated by microarray technique was the key point to assess the biological relevance of the data obtained in terms of Transmissible Spongiform Encephalopathy pathogenesis. Validation of the microarray technique was achieve

SUBMITTER: Tortosa R 

PROVIDER: S-EPMC3225326 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature