BinTree seeking: a novel approach to mine both bi-sparse and cohesive modules in protein interaction networks.

ABSTRACT: Modern science of networks has brought significant advances to our understanding of complex systems biology. As a representative model of systems biology, Protein Interaction Networks (PINs) are characterized by a remarkable modular structures, reflecting functional associations between their components. Many methods were proposed to capture cohesive modules so that there is a higher density of edges within modules than those across them. Recent studies reveal that cohesively interacting modules of proteins is not a universal organizing principle in PINs, which has opened up new avenues for revisiting functional modules in PINs. In this paper, functional clusters in PINs are found to be able to form unorthodox structures defined as bi-sparse module. In contrast to the traditional cohesive

SUBMITTER: Jiao QJ 

PROVIDER: S-EPMC3225364 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature