Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis.

ABSTRACT:

Background

The Oncominedatabase is an online collection of microarrays from various sources, usually cancer-related, and contains many "multi-arrays" (collections of analyzed microarrays, in a single study). As there are often many hundreds of tumour samples/microarrays within a single multi-array results from coexpressed genes can be analyzed, and are fully searchable. This gives a potentially significant list of coexpressed genes, which is important to define pathways in which the gene of interest is involved. However, to increase the likelihood of revealing truly significant coexpressed genes we have analyzed their frequency of occurrence over multiple studies (meta-analysis), greatly increasing the significance of results compared to those of a single study.

Results

We h

SUBMITTER: Wilson BJ 

PROVIDER: S-EPMC3225811 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature