Genome-wide analysis of growth phase-dependent translational and transcriptional regulation in halophilic archaea.

ABSTRACT:

Background

Differential expression of genes can be regulated on many different levels. Most global studies of gene regulation concentrate on transcript level regulation, and very few global analyses of differential translational efficiencies exist. The studies have revealed that in Saccharomyces cerevisiae, Arabidopsis thaliana, and human cell lines translational regulation plays a significant role. Additional species have not been investigated yet. Particularly, until now no global study of translational control with any prokaryotic species was available.

Results

A global analysis of translational control was performed with two haloarchaeal model species, Halobacterium salinarum and Haloferax volcanii. To identify differentially regulated genes, exponentially growing and st

SUBMITTER: Lange C 

PROVIDER: S-EPMC3225822 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature