Activation of PAK by a bacterial type III effector EspG reveals alternative mechanisms of GTPase pathway regulation.

ABSTRACT: Small Rho GTPases regulate a diverse range of cellular behavior within a cell. Their ability to function as molecular switches in response to a bound nucleotide state allows them to regulate multiple dynamic processes, including cytoskeleton organization and cellular adhesion. Because the activation of downstream Rho GTPase signaling pathways relies on conserved structural features of target effector proteins (i.e., CRIB domain), these pathways are particularly vulnerable to microbial pathogenic attack. Here, we discuss new findings for how the bacterial virulence factor EspG from EHEC O157:H7 exploits a CRIB-independent activation mechanism of the Rho GTPase effector PAK. We also compare this mechanism to that of EHEC EspFU, a bacterial virulence factor that directly activates N-WASP. Whi

SUBMITTER: Selyunin AS 

PROVIDER: S-EPMC3225911 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature