Recent advances in understanding the role of nutrition in human genome evolution.

ABSTRACT: Dietary transitions in human history have been suggested to play important roles in the evolution of mankind. Genetic variations caused by adaptation to diet during human evolution could have important health consequences in current society. The advance of sequencing technologies and the rapid accumulation of genome information provide an unprecedented opportunity to comprehensively characterize genetic variations in human populations and unravel the genetic basis of human evolution. Series of selection detection methods, based on various theoretical models and exploiting different aspects of selection signatures, have been developed. Their applications at the species and population levels have respectively led to the identification of human specific selection events that distinguish human

SUBMITTER: Ye K 

PROVIDER: S-EPMC3226386 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature