Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential.

ABSTRACT:

Background

Little justification is generally provided for selection of in vitro assay testing concentrations for engineered nanomaterials (ENMs). Selection of concentration levels for hazard evaluation based on real-world exposure scenarios is desirable.

Objectives

Our goal was to use estimates of lung deposition after occupational exposure to nanomaterials to recommend in vitro testing concentrations for the U.S. Environmental Protection Agency's ToxCast™ program. Here, we provide testing concentrations for carbon nanotubes (CNTs) and titanium dioxide (TiO2) and silver (Ag) nanoparticles (NPs).

Methods

We reviewed published ENM concentrations measured in air in manufacturing and R&D (research and development) laboratories to identify input levels for estimating ENM m

SUBMITTER: Gangwal S 

PROVIDER: S-EPMC3226507 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature