Permanent oviduct posteriorization after neonatal exposure to the phytoestrogen genistein.

ABSTRACT:

Background

Preimplantation embryo loss during oviduct transit has been observed in adult mice after a 5-day neonatal exposure to the phytoestrogen genistein (Gen; 50 mg/kg/day).

Objective

We investigated the mechanisms underlying the contribution of the oviduct to infertility.

Methods

Female mice were treated on postnatal days 1-5 with corn oil or Gen (50 mg/kg/day). We compared morphology, gene expression, and protein expression in different regions of the reproductive tracts of Gen-treated mice with those of control littermates at several time points.

Results

Neonatal Gen treatment resulted in substantial changes in expression of genes that modulate neonatal oviduct morphogenesis, including Hoxa (homeobox A cluster), Wnt (wingless-related MMTV integration sit

SUBMITTER: Jefferson WN 

PROVIDER: S-EPMC3226509 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature