Molecular characterization of China rabies virus vaccine strain.

ABSTRACT:

Background

Rabies virus (RV), the agent of rabies, can cause a severe encephalomyelitis in several species of mammals, including humans. As a human rabies vaccine strain employed in China, the genetic knowledge of the aG strain has not been fully studied. The main goal of the present study is to amplify the whole genome of aG strain, and genetic relationships between other vaccine strains and wild strains were analyzed.

Results

The entire genome of human rabies virus vaccine strain aG employed in China was sequenced; this is the second rabies virus vaccine strain from China to be fully characterized. The overall organization and the length of the genome were similar to that of other lyssaviruses. The length of aG strain was 11925nt, comprising a leader sequence of 58nt, nucl

SUBMITTER: Jiao W 

PROVIDER: S-EPMC3226571 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature