Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells.

ABSTRACT: There is association between exposure to estrogens and the development and progression of hormone-dependent gynecological cancers. Chemical carcinogenesis by catechol estrogens derived from oxidative metabolism is thought to contribute to breast cancer, yet exact mechanisms remain elusive. Malignant transformation was studied in MCF-10A human mammary epithelial cells, since estrogens are not proliferative in this cell line. The human and equine estrogen components of estrogen replacement therapy (ERT) and their catechol metabolites were studied, along with the influence of co-administration of selective estrogen receptor modulators (SERMs), raloxifene and desmethyl-arzoxifene (DMA), and histone deacetylase inhibitors. Transformation was induced by human estrogens, and selectively by the 4-

SUBMITTER: Kastrati I 

PROVIDER: S-EPMC3226622 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature