Calcium-stores mediate adaptation in axon terminals of olfactory receptor neurons in Drosophila.

ABSTRACT:

Background

In vertebrates and invertebrates, sensory neurons adapt to variable ambient conditions, such as the duration or repetition of a stimulus, a physiological mechanism considered as a simple form of non-associative learning and neuronal plasticity. Although various signaling pathways, as cAMP, cGMP, and the inositol 1,4,5-triphosphate receptor (InsP3R) play a role in adaptation, their precise mechanisms of action at the cellular level remain incompletely understood. Recently, in Drosophila, we reported that odor-induced Ca2+-response in axon terminals of olfactory receptor neurons (ORNs) is related to odor duration. In particular, a relatively long odor stimulus (such as 5 s) triggers the induction of a second component involving intracellular Ca2+-stores.

Results

We

SUBMITTER: Murmu MS 

PROVIDER: S-EPMC3226658 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature