Ontology highlight
ABSTRACT:
SUBMITTER: Emanuele MJ
PROVIDER: S-EPMC3226719 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Cell 20110929 2
Cullin-RING ligases (CRLs) represent the largest E3 ubiquitin ligase family in eukaryotes, and the identification of their substrates is critical to understanding regulation of the proteome. Using genetic and pharmacologic Cullin inactivation coupled with genetic (GPS) and proteomic (QUAINT) assays, we have identified hundreds of proteins whose stabilities or ubiquitylation status are regulated by CRLs. Together, these approaches yielded many known CRL substrates as well as a multitude of previo ...[more]