Two distinct routes to oral cancer differing in genome instability and risk for cervical node metastasis.

ABSTRACT:

Purpose

Problems in management of oral cancers or precancers include identification of patients at risk for metastasis, tumor recurrence, and second primary tumors or risk for progression of precancers (dysplasia) to cancer. Thus, the objective of this study was to clarify the role of genomic aberrations in oral cancer progression and metastasis.

Experimental design

The spectrum of copy number alterations in oral dysplasia and squamous cell carcinomas (SCC) was determined by array comparative genomic hybridization. Associations with clinical characteristics were studied and results confirmed in an independent cohort.

Results

The presence of one or more of the chromosomal aberrations +3q24-qter, -8pter-p23.1, +8q12-q24.2, and +20 distinguishes a major subgroup (70%-80%

SUBMITTER: Bhattacharya A 

PROVIDER: S-EPMC3226754 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature