Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40.

ABSTRACT: Commensal flora plays important roles in the regulation of the gene expression involved in many intestinal functions and the maintenance of immune homeostasis, as well as in the pathogenesis of inflammatory bowel diseases. The microRNAs (miRNAs), a class of small, noncoding RNAs, act as key regulators in many biological processes. The miRNAs are highly conserved among species and appear to play important roles in both innate and adaptive immunity, as they can control the differentiation of various immune cells, as well as their functions. However, it is still largely unknown how microbiota regulates miRNA expression, thereby contributing to intestinal homeostasis and pathogenesis of inflammatory bowel disease. In our current study, we found that microbiota negatively regulated intestinal m

SUBMITTER: Xue X 

PROVIDER: S-EPMC3226774 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature