Dynamics in insulin resistance and plasma levels of adipokines in patients with acute decompensated and chronic stable heart failure.

ABSTRACT:

Background

Patients with heart failure (HF) develop metabolic derangements including increased adipokine levels, insulin resistance, inflammation and progressive catabolism. It is not known whether metabolic dysfunction and adipocyte activation worsen in the setting of acute clinical decompensation, or conversely, improve with clinical recovery.

Methods and results

We assessed insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR), and measured plasma levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), adiponectin, visfatin, resistin, leptin, and tumor necrosis factor (TNF) α in 44 patients with acute decompensated HF (ADHF) due to left ventricular (LV) systolic dysfunction and again early (<1 wk) and late (> 6 mo) after clinical r

SUBMITTER: Schulze PC 

PROVIDER: S-EPMC3226951 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature