Stereospecific total synthesis of somocystinamide A.

ABSTRACT: The first total synthesis of somocystinamide A, a disulfide dimer with extremely labile enamide functional groups, was accomplished in a concise and stereospecific manner. Somocystinamide A is reported to possess exceptionally potent antiangiogenic and tumoricidal activities. The current work should enable further pharmacological investigation of this important natural product.

SUBMITTER: Suyama TL 

PROVIDER: S-EPMC3227555 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature