Identifying highly conserved and highly differentiated gene ontology categories in human populations.

ABSTRACT: Detecting and interpreting certain system-level characteristics associated with human population genetic differences is a challenge for human geneticists. In this study, we conducted a population genetic study using the HapMap genotype data to identify certain special Gene Ontology (GO) categories associated with high/low genetic difference among 11 Hapmap populations. Initially, the genetic differences in each gene region among these populations were measured using allele frequency, linkage disequilibrium (LD) pattern, and transferability of tagSNPs. The associations between each GO term and these genetic differences were then identified. The results showed that cellular process, catalytic activity, binding, and some of their sub-terms were associated with high levels of genetic differenc

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC3227580 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature