Abundance of ultramicro inversions within local alignments between human and chimpanzee genomes.

ABSTRACT:

Background

Chromosomal inversion is one of the most important mechanisms of evolution. Recent studies of comparative genomics have revealed that chromosomal inversions are abundant in the human genome. While such previously characterized inversions are large enough to be identified as a single alignment or a string of local alignments, the impact of ultramicro inversions, which are such short that the local alignments completely cover them, on evolution is still uncertain.

Results

In this study, we developed a method for identifying ultramicro inversions by scanning of local alignments. This technique achieved a high sensitivity and a very low rate of false positives. We identified 2,377 ultramicro inversions ranging from five to 125 bp within the orthologous alignments betw

SUBMITTER: Hara Y 

PROVIDER: S-EPMC3227671 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature