Withdrawal from chronic nicotine exposure alters dopamine signaling dynamics in the nucleus accumbens.

ABSTRACT:

Background

Unaided attempts to quit smoking commonly fail during the first 2 weeks of the nicotine withdrawal syndrome. Alterations in dopamine (DA) signaling correlate with withdrawal from chronic nicotine exposure, but those changes have not been well-characterized.

Methods

Mice were administered nicotine in their drinking water for 4 or 12 weeks. Then nicotine was withheld for 1 to 10 days while DA signaling was characterized with in vivo microdialysis or fast-scan cyclic voltammetry.

Results

Upon withdrawal of nicotine, the basal DA concentration in the nucleus accumbens decreased as measured by microdialysis. The length of time that the low basal DA state lasted depended on the length of the chronic nicotine treatment. Microdialysis indicated that acute re-exposu

SUBMITTER: Zhang L 

PROVIDER: S-EPMC3227792 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature