Aspirin for primary prevention of vascular events in women: individualized prediction of treatment effects.

ABSTRACT: AIMS To identify women who benefit from aspirin 100 mg on alternate days for primary prevention of vascular events by using treatment effect prediction based on individual patient characteristics. METHODS AND RESULTS Randomized controlled trial data from the Women's Health Study were used to predict treatment effects for individual women in terms of absolute risk reduction for major cardiovascular events (i.e. myocardial infarction, stroke, or cardiovascular death). Predictions were based on existing risk scores, i.e. Framingham (FRS), and Reynolds (RRS), and on a newly developed prediction model. The net benefit of different aspirin treatment-strategies was compared: (i) treat no one, (ii) treat everyone, (iii) treatment according to the current guidelines (i.e. selective treatment of wom

SUBMITTER: Dorresteijn JA 

PROVIDER: S-EPMC3227855 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature