Effects of mannose-binding lectin polymorphisms on irinotecan-induced febrile neutropenia.

ABSTRACT:

Objective

Mannose-binding lectin (MBL) is important in the innate immune response. MBL2 gene polymorphisms affect MBL expression, and genotypes yielding low MBL levels have been associated with an elevated risk for infections in hematological cancer patients undergoing chemotherapy. However, these reported associations are inconsistent, and data on patients with solid tumors are lacking. Here, we investigated the effects of MBL2 genotypes on irinotecan-induced febrile neutropenia in patients with solid tumors.

Patients and methods

Irinotecan-treated patients were genotyped for the MBL2 gene. Two promoter (-550 H/L and -221 X/Y) and three exon polymorphisms (52 A/D, 54 A/B, and 57 A/C) were determined, together with known risk factors for irinotecan-induced toxicity. Neutrope

SUBMITTER: van der Bol JM 

PROVIDER: S-EPMC3227891 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature