Accurate classification of metastatic brain tumors using a novel microRNA-based test.

ABSTRACT:

Background

Identification of the tissue of origin of a brain metastatic tumor is vital to its management. Carcinoma of unknown primary (CUP) is common in oncology, representing 3%-5% of all invasive malignancies. We aimed to validate a recently developed microRNA-based quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) test for identifying the tumor tissue of origin, first in a consecutive cohort of metastatic tumors of known origin and then in a cohort of CUP cases resected from the central nervous system (CNS).

Patients and methods

One hundred two resected CNS metastatic tumors with known origin, previously classified based on the patient's clinical history and pathological data, as well as a second cohort of resected CNS tumors from 57 patients origina

SUBMITTER: Mueller WC 

PROVIDER: S-EPMC3228095 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature