Potential prognostic biomarkers for bone metastasis from hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) most commonly develops in patients who have a viral infection, especially in the case of hepatitis B virus (HBV), and in patients with a chronic liver disease. HCC patients with bone metastasis (BM) suffer from pain and other symptoms that significantly reduce their quality of life. Identification of patients who are at high risk for BM after undergoing potentially curative treatment for HCC remains challenging. Here, we aimed to identify HCC BM-related genes and proteins to establish prediction biomarkers.

Methods

RNA was extracted from 48 pairs of intratumoral and peritumoral formalin-fixed, paraffin-embedded tissue from HCC patients with and without BM. A cDNA-mediated annealing, selection, extension and ligation assay containing

SUBMITTER: Xiang ZL 

PROVIDER: S-EPMC3228144 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature