GOmotif: A web server for investigating the biological role of protein sequence motifs.

ABSTRACT:

Background

Many proteins contain conserved sequence patterns (motifs) that contribute to their functionality. The process of experimentally identifying and validating novel protein motifs can be difficult, expensive, and time consuming. A means for helping to identify in advance the possible function of a novel motif is important to test hypotheses concerning the biological relevance of these motifs, thus reducing experimental trial-and-error.

Results

GOmotif accepts PROSITE and regular expression formatted motifs as input and searches a Gene Ontology annotated protein database using motif search tools. The search returns the set of proteins containing matching motifs and their associated Gene Ontology terms. These results are presented as: 1) a hierarchical, navigable tree

SUBMITTER: Bristow F 

PROVIDER: S-EPMC3228539 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature