NETGEM: Network Embedded Temporal GEnerative Model for gene expression data.

ABSTRACT:

Background

Temporal analysis of gene expression data has been limited to identifying genes whose expression varies with time and/or correlation between genes that have similar temporal profiles. Often, the methods do not consider the underlying network constraints that connect the genes. It is becoming increasingly evident that interactions change substantially with time. Thus far, there is no systematic method to relate the temporal changes in gene expression to the dynamics of interactions between them. Information on interaction dynamics would open up possibilities for discovering new mechanisms of regulation by providing valuable insight into identifying time-sensitive interactions as well as permit studies on the effect of a genetic perturbation.

Results

We present NETG

SUBMITTER: Jethava V 

PROVIDER: S-EPMC3228555 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature