Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans.

ABSTRACT: One major expectation from the transcriptome in humans is to characterize the biological basis of associations identified by genome-wide association studies. So far, few cis expression quantitative trait loci (eQTLs) have been reliably related to disease susceptibility. Trans-regulating mechanisms may play a more prominent role in disease susceptibility. We analyzed 12,808 genes detected in at least 5% of circulating monocyte samples from a population-based sample of 1,490 European unrelated subjects. We applied a method of extraction of expression patterns-independent component analysis-to identify sets of co-regulated genes. These patterns were then related to 675,350 SNPs to identify major trans-acting regulators. We detected three genomic regions significantly associated with co-regula

SUBMITTER: Rotival M 

PROVIDER: S-EPMC3228821 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature