Prediction of RNA Polymerase II recruitment, elongation and stalling from histone modification data.

ABSTRACT:

Background

Initiation and elongation of RNA polymerase II (RNAPII) transcription is regulated by both DNA sequence and chromatin signals. Recent breakthroughs make it possible to measure the chromatin state and activity of core promoters genome-wide, but dedicated computational strategies are needed to progress from descriptive annotation of data to quantitative, predictive models.

Results

Here, we describe a computational framework which with high accuracy can predict the locations of core promoters, the amount of recruited RNAPII at the promoter, the amount of elongating RNAPII in the gene body, the mRNA production originating from the promoter and finally also the stalling characteristics of RNAPII by considering both quantitative and spatial features of histone modificat

SUBMITTER: Chen Y 

PROVIDER: S-EPMC3228824 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature