Vivax malaria in Mauritania includes infection of a Duffy-negative individual.

ABSTRACT:

Background

Duffy blood group polymorphisms are important in areas where Plasmodium vivax is present because this surface antigen is thought to act as a key receptor for this parasite. In the present study, Duffy blood group genotyping was performed in febrile uninfected and P. vivax-infected patients living in the city of Nouakchott, Mauritania.

Methods

Plasmodium vivax was identified by real-time PCR. The Duffy blood group genotypes were determined by standard PCR followed by sequencing of the promoter region and exon 2 of the Duffy gene in 277 febrile individuals. Fisher's exact test was performed in order to assess the significance of variables.

Results

In the Moorish population, a high frequency of the FYBES/FYBES genotype was observed in uninfected individuals (2

SUBMITTER: Wurtz N 

PROVIDER: S-EPMC3228859 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature