Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop.

ABSTRACT: Although it is recognized that many common complex diseases are a result of multiple genetic and environmental risk factors, studies of gene-environment interaction remain a challenge and have had limited success to date. Given the current state-of-the-science, NIH sought input on ways to accelerate investigations of gene-environment interplay in health and disease by inviting experts from a variety of disciplines to give advice about the future direction of gene-environment interaction studies. Participants of the NIH Gene-Environment Interplay Workshop agreed that there is a need for continued emphasis on studies of the interplay between genetic and environmental factors in disease and that studies need to be designed around a multifaceted approach to reflect differences in diseases, exp

SUBMITTER: Bookman EB 

PROVIDER: S-EPMC3228883 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature