Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes.

ABSTRACT:

Objective

To evaluate the relationship between common genetic variation in genes involved in the biosynthesis and signaling of estrogen and progesterone and endometriosis risk.

Design

Genetic polymorphism analysis.

Setting

Population-based case-control study conducted in Group Health Cooperative enrollees in western Washington.

Patient(s)

Women with newly diagnosed, surgically confirmed endometriosis between 1996 and 2001 (n = 256) and age- and reference year-matched female control subjects without a history of endometriosis (n = 567).

Interventions(s)

None.

Main outcome measure(s)

We evaluated the relationship between common genetic variation and endometriosis risk, using gene-based tests and single-variant analysis of genetic polymorphisms in ES

SUBMITTER: Trabert B 

PROVIDER: S-EPMC3228888 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature