The MetJ regulon in gammaproteobacteria determined by comparative genomics methods.

ABSTRACT:

Background

Whole-genome sequencing of bacteria has proceeded at an exponential pace but annotation validation has lagged behind. For instance, the MetJ regulon, which controls methionine biosynthesis and transport, has been studied almost exclusively in E. coli and Salmonella, but homologs of MetJ exist in a variety of other species. These include some that are pathogenic (e.g. Yersinia) and some that are important for environmental remediation (e.g. Shewanella) but many of which have not been extensively characterized in the literature.

Results

We have determined the likely composition of the MetJ regulon in all species which have MetJ homologs using bioinformatics techniques. We show that the core genes known from E. coli are consistently regulated in other species, and we

SUBMITTER: Augustus AM 

PROVIDER: S-EPMC3228920 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature