Identification of a novel response regulator, Crr1, that is required for hydrogen peroxide resistance in Candida albicans.

ABSTRACT: Candida albicans colonises numerous niches within humans and thus its success as a pathogen is dependent on its ability to adapt to diverse growth environments within the host. Two component signal transduction is a common mechanism by which bacteria respond to environmental stimuli and, although less common, two component-related pathways have also been characterised in fungi. Here we report the identification and characterisation of a novel two component response regulator protein in C. albicans which we have named CRR1 (Candida Response Regulator 1). Crr1 contains a receiver domain characteristic of response regulator proteins, including the conserved aspartate that receives phosphate from an upstream histidine kinase. Significantly, orthologues of CRR1 are present only in fungi belongi

SUBMITTER: Bruce CR 

PROVIDER: S-EPMC3229506 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature