The global transcriptional response of fission yeast to hydrogen sulfide.

ABSTRACT:

Background

Hydrogen sulfide (H(2)S) is a newly identified member of the small family of gasotransmitters that are endogenous gaseous signaling molecules that have a fundamental role in human biology and disease. Although it is a relatively recent discovery and the mechanism of H(2)S activity is not completely understood, it is known to be involved in a number of cellular processes; H(2)S can affect ion channels, transcription factors and protein kinases in mammals.

Methodology/principal findings

In this paper, we have used fission yeast as a model organism to study the global gene expression profile in response to H(2)S by microarray. We initially measured the genome-wide transcriptional response of fission yeast to H(2)S. Through the functional classification of genes whose

SUBMITTER: Jia X 

PROVIDER: S-EPMC3229568 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature