Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems.

ABSTRACT:

Background

Understanding host response to influenza virus infection will facilitate development of better diagnoses and therapeutic interventions. Several different experimental models have been used as a proxy for human infection, including cell cultures derived from human cells, mice, and non-human primates. Each of these systems has been studied extensively in isolation, but little effort has been directed toward systematically characterizing the conservation of host response on a global level beyond known immune signaling cascades.

Results

In the present study, we employed a multivariate modeling approach to characterize and compare the transcriptional regulatory networks between these three model systems after infection with a highly pathogenic avian influenza virus of

SUBMITTER: McDermott JE 

PROVIDER: S-EPMC3229612 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature